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Development of Bevirimat (PA-457): first-in-class HIV maturation inhibitor

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Bevirimat is the first in a new class of HIV drugs called maturation inhibitors that specifically inhibit the last step in processing of Gag, the conversion of capsid-SP1 (p25) to capsid (p24). Following bevirimat treatment, viral particles released from infected cells have abnormal core structures and are non-infectious. The compound is a potent inhibitor of HIV-1 replication and retains activity against drug resistant isolates. It is synergistic with most approved drugs in vitro. Bevirimat is metabolized by glucuronidation and has minimal potential for clinically significant drug interactions.

Bevirimat has good oral bioavailability and long half-life (2.5–3 days) in humans, making it suitable for once-daily oral dosing. It has been well tolerated in clinical studies, following administration to more than 300 people for up to 2 weeks. In a Phase 2a study, 10 days of bevirimat monotherapy at 200 mg/day resulted in >1 log median viral load reduction. A Phase 2b study was recently initiated where bevirimat is being studied in combination with approved drugs in a dose escalation format, in order to identify optimal dose(s) for Phase 3 clinical trials.

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Correspondence to Graham P Allaway.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Load Reduction
  • Approve Drug
  • Significant Drug Interaction
  • Good Oral Bioavailability
  • Median Viral Load