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Parallel dysregulation across psychoimmunological and cardiovascular response systems in HIV+ outpatients
Retrovirology volume 3, Article number: S74 (2006)
Higher Type C coping (under-recognition and under-expression of stress/needs/emotion, and psychological/psychophysiological dyssynchrony) is associated with faster HIV progression. In a pilot study, we found that higher Type C coping was significantly associated with lower HIV-specific antigen-stimulated production of HIV CCR5 co-receptor ligands (beta-chemokines MIP-1α/β), which are potent HIV inhibitors. This study replicates and extends these findings.
Type C coping was assessed using the validated Vignette Similarity Coping Method. In-vitro production of MIP-1α/β in response to the HIV-specific p24 antigen was measured by ELISA from supernatants collected on days 3 and 6. Heart rate and systolic/diastolic blood pressure were recorded every 90 seconds during two emotion-induction tasks, each preceded by a baseline resting period and followed by a recovery period.
Results from the first 100 participants (90% African-American, 55% female) suggest a replication of our previous finding: strong Type C coping is associated with significantly decreased MIP-1α production (r = -1.81, p = .04). In multiple regression analyses adjusted for age and medication use, greater HR reactivity/poorer HR recovery to baseline are significantly associated with decreased MIP-1α/β response to the p24 antigen.
These findings support our central hypothesis that dysregulated coping and physiological patterns are associated with HIV immune responses that contribute to HIV progression.
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Temoshok, L.R., Wald, R.L., Sun, L. et al. Parallel dysregulation across psychoimmunological and cardiovascular response systems in HIV+ outpatients. Retrovirology 3, S74 (2006). https://doi.org/10.1186/1742-4690-3-S1-S74
- Multiple Regression Analysis
- Recovery Period
- Cardiovascular Response
- High Type
- Central Hypothesis