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Open Access

Entry inhibitors as topical microbicides to prevent HIV-1 sexual transmission

  • John P Moore1
Retrovirology20063(Suppl 1):S51

Published: 21 December 2006


PeptideInfectious DiseaseCancer ResearchSmall MoleculeSpecific Inhibitor

Specific inhibitors of HIV-1 attachment, fusion and entry are one approach to a topical microbicide. We have been evaluating several such compounds (small molecules and peptides) targeting several different stages of the fusion process, for their abilities to prevent experimental infection of rhesus macaques with various SHIVs, after vaginal challenge. These results will be presented and discussed, in the context of developing a practical product for use in women and men.

Authors’ Affiliations

Professor of Microbiology and Immunology, Weill Cornell Medical College, New York, USA


© Moore; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd.