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Entry inhibitors as topical microbicides to prevent HIV-1 sexual transmission

Specific inhibitors of HIV-1 attachment, fusion and entry are one approach to a topical microbicide. We have been evaluating several such compounds (small molecules and peptides) targeting several different stages of the fusion process, for their abilities to prevent experimental infection of rhesus macaques with various SHIVs, after vaginal challenge. These results will be presented and discussed, in the context of developing a practical product for use in women and men.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Moore, J.P. Entry inhibitors as topical microbicides to prevent HIV-1 sexual transmission. Retrovirology 3 (Suppl 1), S51 (2006).

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