Skip to content

Advertisement

  • Oral presentation
  • Open Access

Non-neutralizing antibodies and vaccine-induced protection

  • 1,
  • 1,
  • 1,
  • 2,
  • 3,
  • 3,
  • 4,
  • 5,
  • 5,
  • 6,
  • 7,
  • 7 and
  • 1
Retrovirology20063 (Suppl 1) :S26

https://doi.org/10.1186/1742-4690-3-S1-S26

  • Published:

Keywords

  • Rhesus Macaque
  • Passive Transfer
  • Challenge Dose
  • High Challenge
  • Boost Regimen

Neutralizing antibody is critical for sterilizing immunity, but recent data suggest binding antibodies may contribute to protection. A replicating Ad-HIVenv prime/Env protein boost regimen induced potent antibodies with broad antibody-dependent cellular cytotoxic activity (ADCC) across HIV clades. A multigenic Ad-SIV prime/Env subunit boost regimen elicited strong protection in rhesus macaques against SIVmac251. Significant reduction in acute viremia was correlated with non-neutralizing, ADCC-mediating anti-Env antibodies. Further, compared to multigenic vaccines, an Ad-HIVtat+Ad-HIVenv prime/Tat and Env protein boost regimen elicited significantly enhanced protection against SHIV89.6P associated with Tat and Env binding antibodies. Passive transfer of ADCC-mediating IgG has not protected neonatal macaques against oral SIV challenge. But a high challenge dose, limited IgG, and poorly functional or insufficient neonatal NK effector cells may have precluded protection. In future, other challenge routes will be studied in juvenile macaques using more ADCC-mediating IgG.

Authors’ Affiliations

(1)
Vaccine Branch, NCI, NIH, Bethesda, Maryland 20892, USA
(2)
Washington National Primate Research Center, Seattle, Washington 98195, USA
(3)
California National Primate Research Center, Davis, California 95616, USA
(4)
Biostatistics and Data Management Section, NCI, NIH, Bethesda, Maryland 20892, USA
(5)
Advanced BioScience Laboratories, Inc., Kensington, Maryland 20895, USA
(6)
Novartis Vaccines, Emeryville, CA 94608, USA
(7)
National AIDS Center, Istituto Superiore di Sanita, Rome, Italy

Copyright

© Demberg et al; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd.

Advertisement