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Effect of HIV infection on the clinical response of leprosy in Northern Nigeria – a study done in 2005

The clinical features associated with HIV in Adamawa State north eastern Nigeria was done clinically and bacteriologically using Ridley-Jopling classification and bacteriological index respectively. The cases were classified as paucibacillary (Tuberculoid – TT and Borderline Tuberculoid – BTT) and multibacillary (Borderline Borderline – BB, Borderline Lepromatous – BL and Lepromatous Leprosy – LL) Leprosy.

Eleven (10%) of 104 cases were HIV seropositive comprising 7 males and 4 female. Age range was 14 and 63. Among the HIV seropositive patients, those with paucibacillary (PB) were 6 (TT -1, BT -5) while multibacillary (MB) Leprosy 5 (BB-1), BL -2, LL-2). The predominant clinical feature were clawing fingers (64%) ulceration (64%), hand muscle atrophy (5%) and clawing toes (45%). Some clinical feature of paucibacillary leprosy such as sensory loss and hair losses as is also seen in HIV negative patients occurred in increase frequency in HIV positive patients belonging to the multibacillary class. The HIV infected leprosy patients are more likely to manifest advanced stages of the disease than HIV seronegative patient.

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Correspondence to Walter Kalu.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution 2.0 International License (https://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Keywords

  • Muscle Atrophy
  • Leprosy
  • Increase Frequency
  • Negative Patient
  • Hair Loss