- Poster presentation
- Open Access
Increased PD-1 expression in cynomolgus and rhesus macaques during lentiviral infection
© Hokey et al; licensee BioMed Central Ltd. 2006
- Published: 21 December 2006
- Rhesus Macaque
- Costimulatory Molecule
- Peptide Pool
- High Proliferative Capacity
- Infected Monkey
Costimulatory molecules play important roles in immunoregulation. Recent evidence in mice suggests programmed death-1 (PD-1) is a marker for T-cell exhaustion in a murine LCMV model. Here we demonstrate increased PD-1 expression in CD3+ T cells following lentiviral infection in cynomolgus and rhesus macaques with a concomitant increase in CD4+ CD8+ double-positive (DP) T cells. We found DP T cells are PD-1hi and demonstrate a high proliferative capacity in response to lectin stimulation. DP PD-1hi T-cell populations contain functionally active antigen-specific T cells, secreting IFN-γ and expressing CD107a upon stimulation using Gag peptide pools. Finally, we report an inverse correlation between PD-1 expression on CD4 single-positive T cells and CD4+ T-cell counts. Our data indicate PD-1 as a possible marker for immune health during lentiviral infection and suggest higher PD-1 expression in chronically infected monkeys is indicative of T-cell stimulation rather than T-cell exhaustion. To our knowledge, this is the first study of PD-1 expression in non-human primates.
This article is published under license to BioMed Central Ltd.