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  • Open Access

Phylogeny of HTLV-I isolates from groups with risk antecedents for human retrovirus infections in Argentina

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Retrovirology20063 (Suppl 1) :P17

https://doi.org/10.1186/1742-4690-3-S1-P17

  • Published:

Keywords

  • Infectious Disease
  • Cancer Research
  • Package Program
  • Parsimony Tree
  • Positive Individual

Background

HTLV-I infection shows an ethnic-geographic restriction being naturally endemic among aborigines from the Northwest. At-risk populations are also infected with HTLV-I. Cosmopolitan subtype (a) including subgroups A, B and C has been described previously in our country.

Materials and methods

35 HTLV-I samples were analyzed including 3 MSM, 6 FSW (1 from Peru and 3 from Salta), 13 BD (1 Japanese descendent), 5 HAM/TSP (3 from Peru) and 8 HIV positive individuals. The rest were from Buenos Aires (BA) city. LTR regions were amplified by n-PCR. Neighbor-joining and Parsimony trees were performed using Phylip package program.

Results

32 samples were identified as the Cosmopolitan subtype a, subgroup A. One HAM/TSP aA sample from BA was more distantly related to the rest of the aA samples. Furthermore, 2 samples (1 Peruvian HAM/TSP and 1 Japanese BD from BA) clustered with the previously described Br4, Br9 (from Brazil) and B13.Peru.

Conclusion

The majority of the circulating HTLV-I strains in Argentina belonged to the subgroup A. The finding of these 2 samples, clustering separately from any other known HTLV-I subgroup, agrees with previous suggestions of a possible divergent subgroup within subtype a.

Authors’ Affiliations

(1)
National Centre Reference for AIDS, School of Medicine, Buenos Aires, Argentina

Copyright

© Eirin et al; licensee BioMed Central Ltd. 2006

This article is published under license to BioMed Central Ltd.

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