Figure 1

Pre-treatment of naïve rhesus macaques with tenofovir and subsequent infection with SIVmac055. Adult rhesus macaques were treated for 4 weeks with tenofovir at a dose of 30 mg/kg body weight, and then inoculated intravenously with SIVmac055 on day 28 (arrow). Tenofovir treatment was continued for an additional 2 weeks after SIVmac055 infection. Virus replication and CD4⁺ T cell counts were monitored for > 1 year of follow-up. (A) Plasma viral load was measured by real-time PCR with a sensitivity of 50 SIV RNA copies/ml, (B) CD4⁺ T-cell counts.