| Direction | Gene ID | Relevance |
---|---|---|---|
HIV biology | Up | APOBEC3B | Anti-HIV-1 activity [39] |
 |  | CCL3 | An HIV-suppressive factor produced by activated CD8+ T cells [59] |
 |  | EGR1,2 | HIV-1 Tat binds EGRs and induces FasL up-regulation [60] |
 |  | HIVEP3 | A zinc finger protein regulating transcription via the kappa-B enhancer motif [61] |
 |  | IL7R | Correlates with CD4+ T cell depletion in HIV-infected patients [37] |
 |  | TNFSF4 | Enhances HIV-1 replication [40] |
 | Down | DEFA1 | Inhibits HIV-1 replication [41] |
 |  | S100A8, 9, 12 | Induce HIV-1 transcription and replication [42] |
T cell biology | Up | CD25, 69, 96 | Cell activation markers |
 |  | DUSP4,5,6,10 | Involved in MAPK pathway [62–65] |
 |  | PMAIP1 | Involved in p53-mediated apoptosis [66] |
 |  | TNFRSF9 | Inhibits proliferation of activated T lymphocytes, induces programmed cell death [67] |
 | Down | LKLF | T cell quiescence [35] |
 |  | LIME1 | Involved in T cell activation [68] |
 |  | GILZ | Involved in T cell activation, anti-inflammatory and immunosuppressive effects [69, 70] |