Skip to main content

Table 1 Genes relevant to HIV or T cell biology

From: Effects of prostratin on Cyclin T1/P-TEFb function and the gene expression profile in primary resting CD4+T cells

 

Direction

Gene ID

Relevance

HIV biology

Up

APOBEC3B

Anti-HIV-1 activity [39]

  

CCL3

An HIV-suppressive factor produced by activated CD8+ T cells [59]

  

EGR1,2

HIV-1 Tat binds EGRs and induces FasL up-regulation [60]

  

HIVEP3

A zinc finger protein regulating transcription via the kappa-B enhancer motif [61]

  

IL7R

Correlates with CD4+ T cell depletion in HIV-infected patients [37]

  

TNFSF4

Enhances HIV-1 replication [40]

 

Down

DEFA1

Inhibits HIV-1 replication [41]

  

S100A8, 9, 12

Induce HIV-1 transcription and replication [42]

T cell biology

Up

CD25, 69, 96

Cell activation markers

  

DUSP4,5,6,10

Involved in MAPK pathway [62–65]

  

PMAIP1

Involved in p53-mediated apoptosis [66]

  

TNFRSF9

Inhibits proliferation of activated T lymphocytes, induces programmed cell death [67]

 

Down

LKLF

T cell quiescence [35]

  

LIME1

Involved in T cell activation [68]

  

GILZ

Involved in T cell activation, anti-inflammatory and immunosuppressive effects [69, 70]