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Table 4 Definition of mutated HIV-2RODProtease susceptibility to LPV and SQV

From: HIV-2 Protease resistance defined in yeast cells

 

IC50 [μM]

IC50mutant/IC50ROD

HIV-2 Protease mutant

LPV

SQV

LPV

SQV

L90M

12.5+/-8.1

554.1+/-3.9

0.75

3.70

L99F

11.1+/-3.1

147.2+/-5.1

0.67

0.98

  1. L90M and L99F HIV-2ROD mutated Proteases were expressed in yeast. IC50 values to LPV and SQV were defined as in Fig 2A.
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Retrovirology

ISSN: 1742-4690

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