Figure 3
From: Mode of inhibition of HIV-1 Integrase by a C-terminal domain-specific monoclonal antibody*
Non-specific nuclease activity of I267A sIN derivatives. Reaction conditions are described in Materials and Methods. Bl represents a blank reaction in which the enzyme was omitted. (-) indicates duplicate reactions in which the Merck HIV-1 inhibitor L-708,906 was absent. Either 10 or 100 μM of the L-708,906 inhibitor was added as indicated. These concentrations of inhibitor are expected to affect the processing as well as the joining activity of wild type HIV-1 IN [33].