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Table 2 Differentially Expressed Genes between Mock- and Fr57E Non-neurovirulent Virus-infected Microglia

From: Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis

    

Mock-infected

Fr57E-infected

 

probe set

gene

Accession

Function/processa

mean

SE

Callb

mean

SE

Callb

fold change

1425923_at

*neuroblastoma myc-related oncogene 1

M36277

Transcription/cell cycle control

6.96

27.32

A

2189.17

113.3

P

314.68

1425131_at

*protein tyrosine phosphatase, non-receptor type 5

U28216

Tyrosine phosphatase

-101.71

12.11

A

220.58

45.16

A

220.58

1456182_x_at

*melanoma antigen (env polyprotein)

BB795191

retroviral envelope protein

39.08

9.27

A

1057.46

164.85

A

27.06

1427694_at

*gonadotropin releasing hormone receptor

L28756

G-protein coupled receptor

26.1

6.83

A

236.32

27.04

A

9.05

1429212_a_at

*RIKEN cDNA 1700008D07 gene (testis cDNA)

AK005758

Inflammatory response

27.15

6.67

A

200.55

23.75

A

7.39

1422720_at

*ISL1 transcription factor, LIM/homeodomain, (islet-1)

NM_021459

Transcription factor/development

28.05

13.62

A

204.31

17.73

A

7.28

1431213_a_at

*RIKEN cDNA 1300007C21 gene (vaginal cDNA)

BG297038

Retrovirus-related POL polyprotein

43.54

12.85

P

234.29

93.25

P

5.38

1455788_x_at

*Polymerase (DNA-directed), delta interacting protein 3

BB495487

Nucleic acid binding

168.36

116.73

P

832.13

40.86

P

4.94

1452288_at

*expressed sequence BB128963 (neonatal cerebellum)

BG071933

Similar to myotubularin related proteins

64.79

36.28

mA

284.96

32.16

mA

4.4

1450824_at

*patched homolog

NM_008957

Hedgehog receptor

82.11

17.51

A

237.39

24.44

A

2.89

1450610_at

*urocortin

NM_021290

Neuropeptide signaling

66.48

25.27

A

185.56

23.69

A

2.79

1424887_at

kelch domain containing protein 4

BC012312

No annotation

107.6

19.51

mA

254.85

59.56

mA

2.37

1460469_at

*tumor necrosis factor receptor superfamily, member 9

BM250782

Receptor/defense response

148.29

28.95

A

311.04

32.32

mA

2.1

1451107_at

*TBC1 domain family, member 22a

BC023106

GTPase activator activity

296.8

27.95

mA

610.17

47.13

mA

2.06

1449036_at

#Ring finger protein 128

AK004847

(-) regulation of cytokine synthesis

180.46

26.71

P

292.69

27.22

P

1.62

  1. *Genes with asterisks showed differential expression in both Fr57E- and FrCasE-infected microglia when compared to mock-infected microglia (see table 3).
  2. Bolded genes are those that show differential expression only in Fr57E-infected microglia compared to mock-infected microglia.
  3. # This gene was included based on statistical differences (p < 0.05) and its potential immune modulatory function, despite falling below the arbitrary two-fold cut off threshold.
  4. a- Function/process was determined by gene ontology information provided through the Affymetrix NetAffx Analysis Center and its links to PubMed, EMBL, etc.
  5. b-A = Absent call in 5/5 arrays; mA = Absent calls in 3–4/5 arrays; P = Present call in 5/5 arrays; mP = present calls in 3–4/5 arrays
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Retrovirology

ISSN: 1742-4690

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