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Table 2 Differentially Expressed Genes between Mock- and Fr57E Non-neurovirulent Virus-infected Microglia

From: Gene expression profiling of microglia infected by a highly neurovirulent murine leukemia virus: implications for neuropathogenesis

     Mock-infected Fr57E-infected  
probe set gene Accession Function/processa mean SE Callb mean SE Callb fold change
1425923_at *neuroblastoma myc-related oncogene 1 M36277 Transcription/cell cycle control 6.96 27.32 A 2189.17 113.3 P 314.68
1425131_at *protein tyrosine phosphatase, non-receptor type 5 U28216 Tyrosine phosphatase -101.71 12.11 A 220.58 45.16 A 220.58
1456182_x_at *melanoma antigen (env polyprotein) BB795191 retroviral envelope protein 39.08 9.27 A 1057.46 164.85 A 27.06
1427694_at *gonadotropin releasing hormone receptor L28756 G-protein coupled receptor 26.1 6.83 A 236.32 27.04 A 9.05
1429212_a_at *RIKEN cDNA 1700008D07 gene (testis cDNA) AK005758 Inflammatory response 27.15 6.67 A 200.55 23.75 A 7.39
1422720_at *ISL1 transcription factor, LIM/homeodomain, (islet-1) NM_021459 Transcription factor/development 28.05 13.62 A 204.31 17.73 A 7.28
1431213_a_at *RIKEN cDNA 1300007C21 gene (vaginal cDNA) BG297038 Retrovirus-related POL polyprotein 43.54 12.85 P 234.29 93.25 P 5.38
1455788_x_at *Polymerase (DNA-directed), delta interacting protein 3 BB495487 Nucleic acid binding 168.36 116.73 P 832.13 40.86 P 4.94
1452288_at *expressed sequence BB128963 (neonatal cerebellum) BG071933 Similar to myotubularin related proteins 64.79 36.28 mA 284.96 32.16 mA 4.4
1450824_at *patched homolog NM_008957 Hedgehog receptor 82.11 17.51 A 237.39 24.44 A 2.89
1450610_at *urocortin NM_021290 Neuropeptide signaling 66.48 25.27 A 185.56 23.69 A 2.79
1424887_at kelch domain containing protein 4 BC012312 No annotation 107.6 19.51 mA 254.85 59.56 mA 2.37
1460469_at *tumor necrosis factor receptor superfamily, member 9 BM250782 Receptor/defense response 148.29 28.95 A 311.04 32.32 mA 2.1
1451107_at *TBC1 domain family, member 22a BC023106 GTPase activator activity 296.8 27.95 mA 610.17 47.13 mA 2.06
1449036_at #Ring finger protein 128 AK004847 (-) regulation of cytokine synthesis 180.46 26.71 P 292.69 27.22 P 1.62
  1. *Genes with asterisks showed differential expression in both Fr57E- and FrCasE-infected microglia when compared to mock-infected microglia (see table 3).
  2. Bolded genes are those that show differential expression only in Fr57E-infected microglia compared to mock-infected microglia.
  3. # This gene was included based on statistical differences (p < 0.05) and its potential immune modulatory function, despite falling below the arbitrary two-fold cut off threshold.
  4. a- Function/process was determined by gene ontology information provided through the Affymetrix NetAffx Analysis Center and its links to PubMed, EMBL, etc.
  5. b-A = Absent call in 5/5 arrays; mA = Absent calls in 3–4/5 arrays; P = Present call in 5/5 arrays; mP = present calls in 3–4/5 arrays