Volume 2 Supplement 1

2005 International Meeting of The Institute of Human Virology

Open Access

Prime-boost AIDS Vaccine Strategies Based on Replication-Competent Adenovirus Recombinants

  • Bo Peng1,
  • Nina Malkevitch1,
  • L Jean Patterson1,
  • V Raúl Gómez-Román1, 2,
  • David Venzon3,
  • Ruth Florese1,
  • Indresh Srivastava2,
  • Susan W Barnett2 and
  • Marjorie Robert-Guroff1Email author
Retrovirology20052(Suppl 1):S64

https://doi.org/10.1186/1742-4690-2-S1-S64

Published: 8 December 2005

The potent, persistent immunity needed to prevent HIV infection might be best achieved by priming cellular immunity with replicating vectors and boosting antibodies with optimally designed envelopes. Replicating Ad vaccines infect epithelial cells on mucosal surfaces and thus also elicit mucosal immunity. In chimpanzees, compared to non-replicating Ad vaccines, at the same or lower dose replicating Ad vaccines were better at eliciting cellular immunity and priming antibody responses. Mismatched envelope boosts induced broad neutralizing activity to diverse R5 viruses and cross-clade ADCC activity. Multigenic Ad-SIV vaccines and SIV envelope subunit boosts elicited strong protection in 39% of rhesus macaques challenged mucosally with SIVmac251. Durability of protection against a second challenge was established in 73% of previously protected animals, associated with persistent cellular immunity. Induction of memory cells and broad, strong functional antibodies illustrates the promise of this prime-boost vaccine strategy.

Notes

Authors’ Affiliations

(1)
Vaccine Branch
(2)
Chiron Corporation
(3)
Biostatistics and Data Management Section, NCI

Copyright

© The Author(s) 2005

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