Skip to main content

Integration of HIV-1 Caused STAT3-Associated B Cell Lymphoma in an AIDS Patient

B cell lymphomas remain a significant cause of morbidity in AIDS but the pathophysiology of this disease is unclear. We report a case of B cell lymphoma in which HIV-1 integrated into the host genome. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of a homosexual AIDS patient. The lymphoma cells did not express KSHV-LANA and EBV-EBER or HIV-1 p24 but did express high levels of nuclear localized STAT3. The provirus had a 5'LTR deletion and the 3'LTR was inserted just before the first coding exon of STAT3. Reporter gene assay demonstrated that the 3'LTR had a strong promoter activity especially when co-transfected with HIV Tat. These data suggest HIV-1 integration resulted in induction of STAT3 and possibly promoted lymphoma formation. This suggests that HIV-1 insertional mutagenesis may be associated with some cases of AIDS lymphoma.

Author information

Affiliations

Authors

Corresponding author

Correspondence to Harutaka Katano.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Katano, H., Sato, Y., Hoshino, S. et al. Integration of HIV-1 Caused STAT3-Associated B Cell Lymphoma in an AIDS Patient. Retrovirology 2, S53 (2005). https://doi.org/10.1186/1742-4690-2-S1-S53

Download citation

Keywords

  • Lymphoma
  • Reporter Gene
  • Promoter Activity
  • Cell Lymphoma
  • Cell Morphology