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  • Oral presentation
  • Open Access

Integration of HIV-1 Caused STAT3-Associated B Cell Lymphoma in an AIDS Patient

  • 1Email author,
  • 1,
  • 2,
  • 3,
  • 1,
  • 2 and
  • 2
Retrovirology20052 (Suppl 1) :S53

https://doi.org/10.1186/1742-4690-2-S1-S53

  • Published:

Keywords

  • Lymphoma
  • Reporter Gene
  • Promoter Activity
  • Cell Lymphoma
  • Cell Morphology

B cell lymphomas remain a significant cause of morbidity in AIDS but the pathophysiology of this disease is unclear. We report a case of B cell lymphoma in which HIV-1 integrated into the host genome. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of a homosexual AIDS patient. The lymphoma cells did not express KSHV-LANA and EBV-EBER or HIV-1 p24 but did express high levels of nuclear localized STAT3. The provirus had a 5'LTR deletion and the 3'LTR was inserted just before the first coding exon of STAT3. Reporter gene assay demonstrated that the 3'LTR had a strong promoter activity especially when co-transfected with HIV Tat. These data suggest HIV-1 integration resulted in induction of STAT3 and possibly promoted lymphoma formation. This suggests that HIV-1 insertional mutagenesis may be associated with some cases of AIDS lymphoma.

Notes

Authors’ Affiliations

(1)
Department of Pathology, National Institute of Infectious Diseases, Tokyo 162-8640, Japan
(2)
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, NY 10016, USA
(3)
Department of Pathology, Teikyo University School of Medicine, Tokyo 173-8605, Japan

Copyright

© The Author(s) 2005

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