Skip to content

Advertisement

  • Oral presentation
  • Open Access

Integration of HIV-1 Caused STAT3-Associated B Cell Lymphoma in an AIDS Patient

  • 1Email author,
  • 1,
  • 2,
  • 3,
  • 1,
  • 2 and
  • 2
Retrovirology20052(Suppl 1):S53

https://doi.org/10.1186/1742-4690-2-S1-S53

Published: 8 December 2005

Keywords

  • Lymphoma
  • Reporter Gene
  • Promoter Activity
  • Cell Lymphoma
  • Cell Morphology

B cell lymphomas remain a significant cause of morbidity in AIDS but the pathophysiology of this disease is unclear. We report a case of B cell lymphoma in which HIV-1 integrated into the host genome. The lymphoma cells with anaplastic large cell morphology formed multiple nodular lesions in the lung of a homosexual AIDS patient. The lymphoma cells did not express KSHV-LANA and EBV-EBER or HIV-1 p24 but did express high levels of nuclear localized STAT3. The provirus had a 5'LTR deletion and the 3'LTR was inserted just before the first coding exon of STAT3. Reporter gene assay demonstrated that the 3'LTR had a strong promoter activity especially when co-transfected with HIV Tat. These data suggest HIV-1 integration resulted in induction of STAT3 and possibly promoted lymphoma formation. This suggests that HIV-1 insertional mutagenesis may be associated with some cases of AIDS lymphoma.

Notes

Authors’ Affiliations

(1)
Department of Pathology, National Institute of Infectious Diseases, Tokyo, Japan
(2)
Division of Pulmonary and Critical Care Medicine, New York University School of Medicine, USA
(3)
Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan

Copyright

© The Author(s) 2005

Advertisement