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HIV-1 Escape From Small Molecule CCR5 Inhibitors In Vitro

We have generated HIV-1 isolates that are resistant to several small molecule CCR5 inhibitors by serial passage in vitro. We have investigated the molecular basis of this resistance through genetic and phenotypic studies. We find that different genetic pathways leading to small molecule inhibitor resistance can be taken by the same starting virus. Additionally, these viruses can exhibit different levels of cross resistance to RANTES derivatives. These studies provide insight into potential mechanisms of CCR5 inhibitor resistance.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Kuhmann, S. HIV-1 Escape From Small Molecule CCR5 Inhibitors In Vitro. Retrovirology 2 (Suppl 1), S5 (2005).

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