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Conformational Changes in the HIV/SIV Envelope Glycoprotein

The crystallographically determined structures of unliganded, fully glycosylated SIV gp120 core (Chen et al, 2005) and of HIV gp120 core with bound CD4 and Fab 17b (Kwong et al, 1998) together allow us to visualize the conformational changes that occur in gp120 upon binding of receptor and co-receptor.

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Correspondence to Stephen C Harrison.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Chen, B., Vogan, E. & Harrison, S.C. Conformational Changes in the HIV/SIV Envelope Glycoprotein. Retrovirology 2 (Suppl 1), S2 (2005).

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