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  • Oral presentation
  • Open Access

Conformational Changes in the HIV/SIV Envelope Glycoprotein

Retrovirology20052 (Suppl 1) :S2

https://doi.org/10.1186/1742-4690-2-S1-S2

  • Published:

Keywords

  • Infectious Disease
  • Cancer Research
  • Conformational Change
  • Envelope Glycoprotein
  • Gp120 Core

The crystallographically determined structures of unliganded, fully glycosylated SIV gp120 core (Chen et al, 2005) and of HIV gp120 core with bound CD4 and Fab 17b (Kwong et al, 1998) together allow us to visualize the conformational changes that occur in gp120 upon binding of receptor and co-receptor.

Notes

Authors’ Affiliations

(1)
Children's Hospital and Harvard Medical School, Boston, MA 02115, USA
(2)
Howard Hughes Medical Institute, USA

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