Volume 2 Supplement 1

2005 International Meeting of The Institute of Human Virology

Open Access

Conformational Changes in the HIV/SIV Envelope Glycoprotein

Retrovirology20052(Suppl 1):S2


Published: 8 December 2005

The crystallographically determined structures of unliganded, fully glycosylated SIV gp120 core (Chen et al, 2005) and of HIV gp120 core with bound CD4 and Fab 17b (Kwong et al, 1998) together allow us to visualize the conformational changes that occur in gp120 upon binding of receptor and co-receptor.


Authors’ Affiliations

Children's Hospital and Harvard Medical School
Howard Hughes Medical Institute


© The Author(s) 2005