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Mechanisms Contributing to Control of Viremia

Comparison of different cohorts of SIV-infected rhesus macaques that control viremia may help to identify the mechanisms that prevent progression towards AIDS. We study 3 groups of macaques able to control viremia to various extents. Group 1 was infected with live-attenuated Rev-independent SIV is able to persistently control viremia over more than 7 years. Group 2 are live-attenuated SIV-infected macaques additionally challenged with pathogenic SIVmac251 and controls the challenge to various levels (<105 copies/ml) for more than 4 years. Group 3 are SIVmac251-infected animals therapeutically immunized using DNA vectors during ART. These animals control viremia after release from ART for more than 18 months (<104 copies/ml). Animals in groups 1 and 2 developed long-lasting humoral and cellular immune responses. Animals in group 3 have persistent increases in cellular and humoral responses leading to virus containment and slower onset of disease. The understanding of the underlying mechanism leading to protective immune responses of these 3 cohorts of 'controllers' will be useful for rational vaccine design.

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Correspondence to Barbara K Felber.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Felber, B.K. Mechanisms Contributing to Control of Viremia. Retrovirology 2 (Suppl 1), S145 (2005).

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