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  • Poster presentation
  • Open Access

Replication of Significant Relationship Between MIP-1β Production Following p24 Stimulation and Type C Coping

  • 1, 2Email author,
  • 2,
  • 2,
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  • 3
Retrovirology20052 (Suppl 1) :P114

  • Published:


  • Infectious Disease
  • Cancer Research
  • Longitudinal Study
  • Significant Relationship
  • Similarity Rate


We have shown that the Type C style of coping with stress (diminished ability to recognize and express stress/ distress/emotions) is related to HIV progression. We recently found in a study of 50 HIV+ patients in Baltimore, that stronger Type C coping is associated with decreased production of beta-chemokines that bind to the HIV co-receptor CCR5. Under the aegis of NIH, we have initiated a longitudinal study with a final N = 200 to evaluate the core hypothesis that lower production of the beta-chemokines MIP-1 α/β mediates the relationship between Type C coping and HIV progression.


Type C coping was assessed using Temoshok's Vignette Similarity Rating Method. Measurement of antigen-induced chemokine production from subjects' blood followed methods described in Garzino-Demo et a. PNAS 1999. Cells were incubated with media alone (control), p24 antigen, PHA, or candida. Supernatants were collected on day 3 and 6 for beta- chemokine measurements. Assays for MIP-1α/β were performed by commercial ELISA for the first 47 subjects.


Subjects who scored high on Type C coping (3,4,5) had a significantly lower mean stimulation index for MIP-1β by p24, compared to subjects low on Type C coping (2.7 vs. 5.0).


This replication in a separate sample strengthens our hypothesis about mechanisms mediating HIV progression.


Authors’ Affiliations

Dept Medicine, Univ Maryland School Med, Baltimore, 21201, San Francisco State Univ, CA, USA
Institute of Human Virology, Univ Maryland Biotechnol Inst, San Francisco State Univ, CA, USA
Public Research Institute, San Francisco State Univ, CA, USA


© The Author(s) 2005