Skip to main content

Replication of Significant Relationship Between MIP-1β Production Following p24 Stimulation and Type C Coping


We have shown that the Type C style of coping with stress (diminished ability to recognize and express stress/ distress/emotions) is related to HIV progression. We recently found in a study of 50 HIV+ patients in Baltimore, that stronger Type C coping is associated with decreased production of beta-chemokines that bind to the HIV co-receptor CCR5. Under the aegis of NIH, we have initiated a longitudinal study with a final N = 200 to evaluate the core hypothesis that lower production of the beta-chemokines MIP-1 α/β mediates the relationship between Type C coping and HIV progression.


Type C coping was assessed using Temoshok's Vignette Similarity Rating Method. Measurement of antigen-induced chemokine production from subjects' blood followed methods described in Garzino-Demo et a. PNAS 1999. Cells were incubated with media alone (control), p24 antigen, PHA, or candida. Supernatants were collected on day 3 and 6 for beta- chemokine measurements. Assays for MIP-1α/β were performed by commercial ELISA for the first 47 subjects.


Subjects who scored high on Type C coping (3,4,5) had a significantly lower mean stimulation index for MIP-1β by p24, compared to subjects low on Type C coping (2.7 vs. 5.0).


This replication in a separate sample strengthens our hypothesis about mechanisms mediating HIV progression.

Author information

Authors and Affiliations


Corresponding author

Correspondence to Lydia Temoshok.

Rights and permissions

Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Reprints and permissions

About this article

Cite this article

Temoshok, L., Garzino-Demo, A., Wald, R. et al. Replication of Significant Relationship Between MIP-1β Production Following p24 Stimulation and Type C Coping. Retrovirology 2 (Suppl 1), P114 (2005).

Download citation

  • Published:

  • DOI: