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Figure 2 | Retrovirology

Figure 2

From: Amino acid residues that are important for Hyal2 function as a receptor for jaagsiekte sheep retrovirus

Figure 2

Receptor activity of mouse/human receptor chimeras. Scale drawings of human (open boxes), C3H mouse (black boxes) and chimeric Hyal2 receptors are shown. Receptor activities following transfection of NIH 3T3 mouse cells are indicated at right and are expressed as a percentage of that of human Hyal2. The top diagram shows the positions of the signal peptide (amino acids 1–20), the GPI anchor addition site (after amino acid 447), and the amino acid positions where the Hyal2 cDNAs were recombined. The human Hyal2 [GenBank:U09577.1] and C3H mouse Hyal2 [GenBank:AF302843.1] sequences used here have been described. The Hyal2 protein sequence of C3H mice is identical to that of NIH Swiss mice [GenBank:AF535140.1], and differs by one amino acid (V at position 355) from that of Czech II mice [GenBank:AF302844.1] (I at position 355).

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Retrovirology

ISSN: 1742-4690

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