Figure 3

Alignments of orthologous and paralogous MaLR-e1 LTR sequences from mammalian species. Sequences were assembled using the human sequence (HOM) as reference. Orthologous sequences are from the following origin: HOM: Homo sapiens, PAN: Pan troglodytes, GOR: Gorilla gorilla, ORA:Pongo pygmaeus, GIB: Hylobatides pileatus, ATE: Ateles fusciceps robustus, CAL: Callithrix jacchus, OTO: Otolemur garnetti, CAN: Canis familiaris, DAS: Dasypus novemcictus. Hs12, hs5 and hs20 correspond to MaLR-e1 putative paralogous sequences isolated in the human genome. 5' and 3' openboxes corresponds to MLT1J2 and MLT1J Repbase consensuses, respectively. The region with grey background indicates the 5' or 3' boundaries zone of most partial MaLR-e1 in human and dog genomes. Four putative 3' boundaries of the MaLR-e1 LTR are shown as vertical bars. The double head arrow delimits the trophoblastic specific enhancer (TSE). * correspond to the location of the omitted ERVWE1 provirus. Direct repeats flanking the ERVWE1 integration site are underlined. Bold gray characters in the 3' end of DAS and CAN sequences precede large insertions (1,3 kb and 4,5 kb, respectively) omitted in the alignment.