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Archived Comments for: Valproic acid and HIV-1 latency: beyond the sound bite

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  1. Research Follow Up

    John Gargan, Project Samaritan Residential

    8 September 2008

    Has there been any follow up to this research? If so, where can I find the information.

    Thank you very much


    Competing interests

    None declared

  2. follow up

    Kuan-Teh Jeang, NIH

    8 September 2008

    Three articles that followup the original findings on valproic acid:

    1: DiCenzo R, Peterson DR, Cruttenden K, Mariuz P, Rezk NL, Hochreiter J, Gelbard H, Schifitto G.

    Effects of minocycline and valproic acid coadministration on atazanavir plasma

    concentrations in human immunodeficiency virus-infected adults receiving atazanavir-ritonavir.

    Antimicrob Agents Chemother. 2008 Sep;52(9):3035-9. Epub 2008 Jun 23. PMID: 18573930 [PubMed - in process]

    2: Archin NM, Eron JJ, Palmer S, Hartmann-Duff A, Martinson JA, Wiegand A, Bandarenko N, Schmitz JL, Bosch RJ, Landay AL, Coffin JM, Margolis DM.

    Valproic acid without intensified antiviral therapy has limited impact on persistent HIV infection of resting CD4+ T cells. AIDS. 2008 Jun 19;22(10):1131-5.

    PMID: 18525258 [PubMed - indexed for MEDLINE]

    3: Sagot-Lerolle N, Lamine A, Chaix ML, Boufassa F, Aboulker JP, Costagliola D, Goujard C, Paller C, Delfraissy JF, Lambotte O; ANRS EP39 study. Prolonged valproic acid treatment does not reduce the size of latent HIV reservoir. AIDS. 2008 Jun 19;22(10):1125-9.

    PMID: 18525257 [PubMed - indexed for MEDLINE]

    Competing interests