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Figure 4 | Retrovirology

Figure 4

From: Conservation of functional domains and limited heterogeneity of HIV-1 reverse transcriptase gene following vertical transmission

Figure 4

Multiple sequence alignment of deduced amino acids of HIV-1 reverse transcriptase (RT) gene from mother-infant pair D. The patient sequences are aligned in reference to consensus RT sequence of HIV-1 subtype or clade B (CON B) at the top. In the mother-infant pair sequences, each line refers to a clone identified by a clone number with M referring to mother and I to infants. The structural elements of RT are indicated above the alignment. Dots represent amino acid agreement with CON-B and substitutions are shown by single letter codes for the changed amino acid. Stop codons are shown as x and dashes represent gaps or truncated protein. Relevant amino acid motifs and domains essential for RT activity are shown by spanning arrowheads indicated above the alignment.

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