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  • Open Access

Seroprevalence of Human T-lymphotropic virus type-1 and -2 infections among first-time United States Blood Donors 2000-2009

  • 1, 2,
  • 2,
  • 2,
  • 3,
  • 3,
  • 3,
  • 3,
  • 3 and
  • 4, 2
Retrovirology201411 (Suppl 1) :P61

https://doi.org/10.1186/1742-4690-11-S1-P61

  • Published:

Keywords

  • Confidence Interval
  • Logistic Regression
  • Infectious Disease
  • Cancer Research
  • Demographic Characteristic

Background

Human T-lymphotropic virus types 1 and 2 (HTLV-1 and –2) are prevalent at low-level among United States blood donors, but recent data on their prevalence is lacking.

Methods

Data on all first-time blood donors in a large network of United States blood centers was examined during the period 2000-2009. Anti-HTLV-1 and -2 was measured by enzyme immunoassay (EIA) screening with type-specific confirmation by immunofluorescence or RIBA. Prevalence and odds ratios (OR) and 95% confidence intervals (CI) for associations with demographic characteristics were assessed using multivariable logistic regression.

Results

Among 2,047,740 first-time donors, 104 donors were seropositive for HTLV-I (prevalence 5.1 (95% CI: 4.1 - 6.1) per 100,000) and 300 donors were seropositive for HTLV-2 infection (prevalence 14.7 (95% CI 13.0 - 16.3) per 100,000). Prevalence was lower than reported in the 1990’s but stable from 2000 to 2009. HTLV-1 seropositivity was associated with female sex (OR = 1.56, 95% CI 1.05-2.32); older age; and Black (IR = 25.29, 9% CI 13.14- 48.68) and Asian (OR = 21.43, 95% CI 10.31-44.53) race/ethnicity. HTLV-2 seropositivity was associated with female sex (OR = 2.13, 95% CI 1.67-2.73); older age; and non-white race/ethnicity; residence in the Western (OR=4.12, 95% CI 2.16-7.82) and Southwestern (OR=2.47, 95% CI 1.28-4.78; both vs. Northern) U.S.; and lower educational level.

Conclusions

HTLV-1 and -2 prevalences among U.S. blood donors declined since the early 1990’s but were stable since 2000. Higher prevalence of HTLV-2 in the West and Southwest may be attributed to endemic foci among Amerindians.

Authors’ Affiliations

(1)
Department of Biostatistics, Columbia University, New York, NY, USA
(2)
Blood Systems Research Institute, San Francisco, CA, USA
(3)
Blood Systems, Inc., Scottsdale, AZ, USA
(4)
Departments of Laboratory Medicine and Epidemiology/Biostatistics, University of California San Francisco, San Francisco, CA, USA

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