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Epidemiological features of BLV natural infection

Dairy farms are heavily infected with Bovine Leukemia Virus (BLV) in Argentina and many other countries, where a control strategy should be design based on the behavior of natural. We conducted a series of studies with the aim to better understand the epidemiology of BLV. Infected new born calves were present in 3 studied farms (8.3%-11%). Proviral load (PVL) was very low in 9/10 new born analyzed calves but rapidly augmented during the first months of age. Cross-sectional studies showed that the rate of high PVL between seroreactors raised together with the prevalence, from 20.2% at 8 months of age to 44.4% in 26 months heifers, with similar levels to adult lactating cows of the same farm. Low fluctuation of blood PVL was observed on animals with naturally-acquired infections. We also observed 10 seroconversions between young heifers with an initial elevation of PVl. The presence of provirus in colostrum was significantly correlated with blood PVL (p≤0.0001). Provirus in milk was detectable in bulk tank (17.2%) and individual samples (40.4%). Colostrum of individual cows showed different provirus/antibodies dual profiles that permit to speculate about different infective/protective potential among infected animals. These findings suggest animals would be exposed to the infective challenge since a very young age. Consequently, it must be control as soon as possible after birth. The main focus should be put on the new-born infected calves that could play the role of main propagators together with the putative oral exposition through colostrum and milk.

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Correspondence to Karina Trono.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver ( ) applies to the data made available in this article, unless otherwise stated.

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Lomonaco, M., Alvarez, I., Martínez, C. et al. Epidemiological features of BLV natural infection. Retrovirology 11 (Suppl 1), P45 (2014).

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