Volume 11 Supplement 1

16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

HTLV-1 proviral load in adult T-cell leukemia/lymphoma (ATLL) patients from non-endemic regions of Argentina

  • Andrea Mangano1Email author,
  • María Saliba Pineda1,
  • Patricia Costantini2,
  • María Belén Bouzas3,
  • Cecilia Chidid4,
  • Griselda Di Stefano5,
  • Ana Inés Varela4,
  • Natalia Altamirano1,
  • Luciana Tadey3,
  • Lilia Mammana3,
  • Paula Aulicino1,
  • Liliana Olivares6 and
  • Luisa Sen1
Retrovirology201411(Suppl 1):P34


Published: 7 January 2014

Few ATLL cases have been reported in the country, the majority of the acute leukemia subtype. HTLV-1 proviral load is considered a prognosis marker and it has been available in our setting since 2008. We present HTLV-1 proviral loads in 3 cases of ATLL received during the last 4 years. Two cases were of the acute subtype and one case of the lymphoma subtype. All were male with ages of 49, 34 and 54, respectively at diagnosis. Both acute cases were treated with CHOP chemotherapy. One was responder and one was chemo resistant. The latter after several treatments had disease progression and died 16 months after diagnosis. HTLV-1 proviral load was only measured at 10 months from diagnosis and was 5.3 log10/106 PBMC. The acute responder case had several measures of proviral load after clinical remission post-CHOP and during antiretroviral treatment plus alpha interferon. The proviral load was high but stable during almost four years (5.36 log10/106 PBMC). Afterwards, the patient was stopping treatment with interferon. Proviral load was 5.16 log10/106 PBMC and 6 log10/106 PBMC after one and 6 months, respectively. The lymphoma case was recently diagnosed (February 2013) had a proviral load of 3,76 log10/106 PBMC at that time and is currently untreated. The two acute leukemia cases showed similarly high proviral loads despite differences in survival time and response to treatment. Otherwise, in the lymphoma case proviral load was lower than in the acute leukemia cases. Further proviral load studies are needed to confirm this preliminary finding.

Authors’ Affiliations

Laboratorio de Biología Celular y Retrovirus- CONICET, Hospital Garrahan, Ciudad Autónoma de Buenos Aires
División de Infectología, Hospital Angel H. Roffo, Ciudad Autónoma de Buenos Aires
Unidad de Virología, Hospital Muñiz, Ciudad Autónoma de Buenos Aires
Clínica Angelus, San Isidro, Provincia de Buenos Aires
División de Hematología, Hospital Angel H. Roffo, Ciudad Autónoma de Buenos Aires
Unidad Dermatología, Hospital Muñiz, Ciudad Autónoma de Buenos Aires


© Mangano et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.