Volume 11 Supplement 1

16th Interntional Conference on Human Retroviruses: HTLV and Related Viruses

Open Access

Neuropsychological assessment in HTLV-1 infection: Preliminary data of a comparative study among depression and neurocognitive impairments

  • Maria Rita Polo Gascón1,
  • Yolanda Marques Mazzaro1,
  • Claudio Garcia Capitão1,
  • Vilma BL Ferreira Jardim1,
  • Guilherme Sciascia Olival1,
  • José Vidal Bermudez1,
  • Casseb Jorge2,
  • Smid Jerusa1,
  • Penalva Oliveira1 and
  • Augusto César1
Retrovirology201411(Suppl 1):P32


Published: 7 January 2014

The main goal of this present study was to investigate the presence of neurocognitive impairments in patients infected by HTLV-1 virus, associated with different levels of depression. 24 of the 150 patients regularly attending in the outpatient clinic of the HTLV at the Institute of Infectious Diseases Emilio Ribas, were evaluated by the team of neuropsychology and distributed into two groups, one with a degree of depression minimal / mild (n = 14) and another with moderate / severe (n = 10). 17 were female and 7 male, mean age 53.33 (SD = 11.9), average schooling 6.6 years (SD = 2.8), and 16 had HAM / TSP. The study delineation was observational and descriptive. The instruments used were the Beck Depression Inventory (BDI) to assess the depression state, plus a Neuropsychological Battery with the aim of assessing memory, language, and intellectual and motor functioning, attentional and executive functions. Data were analyzed by calculating averages, frequency and Spearman correlation (SPSS21v). The patients with higher levels of depression had worse performance on several cognitive domains. However, the neurocognitive deficits with statistical significance were found in tasks that assessed auditory memory post interference (p = 0.035) , sustained attention (p = 0.020) and motor speed (dominant hand = p = 0.02 / non-dominant hand p = 0.030). These preliminary data suggest that the neurocognitive performance may be related to the degree of depression and not solely the action of virus in the central nervous system.

Authors’ Affiliations

Institute of Infectious Diseases “Emilio Ribas”
Institute of Tropical Medicine of Sao Paulo- USP


© Gascón et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.