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  • Open Access

HTLV-1 associated bronchiectasis among Indigenous Australians is associated with higher HTLV-1 proviral loads: Results of a prospective case-control study

  • 1Email author,
  • 2, 3,
  • 4,
  • 1 and
  • 2, 3
Retrovirology201411 (Suppl 1) :P28

https://doi.org/10.1186/1742-4690-11-S1-P28

  • Published:

Keywords

  • Dermatitis
  • Bronchiectasis
  • Thiabendazole
  • Pasteur Institute
  • Strongyloidiasis

Infection with HTLV-1 is associated with bronchiectasis in Indigenous Australians. Previous studies have not determined HTLV-1 proviral loads (pvl), which predict risk of other HTLV-1 associated inflammatory diseases, such as HTLV-1 associated myelopathy. Thirty-six Indigenous adults admitted to Alice Springs Hospital, June 2008 to December 2009, with radiologically confirmed bronchiectasis, but no other HTLV-1 related disease, were prospectively recruited and matched by age and sex to 36 controls of the same ethno-geographic origin. Case notes were reviewed from date of birth or first admission to date of recruitment. HTLV-1 subtype C pvl were determined at the Pasteur Institute, Paris. HTLV-1 infection was more common among cases (25/36; 69.4%) than their controls (15/36; 41.7%)(p<0.018). Two cases were admitted in childhood with probable infective dermatitis and two with recurrent strongyloidiasis unresponsive to treatment with thiabendazole. In adulthood, cases (25/36; 69%) were more likely than controls (5/25; 20%) to have positive or borderline strongyloides serology (p<0.001). The mean HTLV-1 pvl (±SEM) was significantly higher for cases (0.83±0.21% PBMC) than controls (0.12±0.05% PBMC)(p=0.016) and was nearly17 fold-higher compared to controls in which bronchiectasis was excluded by HRCT (0.05±0.02% PBMC; p=0.006). Twelve cases (33.3%) and 5 controls (13.9%) died during 3 years of follow-up (p<0.052). Cases died at a younger age (cases, 49±15; controls, 60±13)(p=0.15). In both groups HTLV-1 infected patients were more likely to die: cases, 11/12 (92%); controls, 4/5 (80%). HTLV-1-associated bronchiectasis is associated with higher HTLV-1 pvl suggesting that this condition results from an HTLV-1 driven inflammatory process.

Authors’ Affiliations

(1)
Flinders University/Northern Territory Rural Clinical School, Alice Springs Hospital, Northern Territory, Australia
(2)
Département de Virologie, Institut Pasteur, Unité d’Epidémiologie et Physiopathologie des Virus Oncogènes, Paris, France
(3)
CNRS, UMR 3569 Paris, France
(4)
Department of Paediatrics, Alice Springs Hospital, Northern Territory, Australia

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