Skip to content


  • Poster presentation
  • Open Access

Contribution of galvanic vestibular stimulation for the diagnosis of HAM/TSP

  • 1, 2,
  • 1, 2,
  • 1, 3,
  • 2,
  • 2,
  • 1, 2 and
  • 1, 2Email author
Retrovirology201411 (Suppl 1) :P27

  • Published:


  • Progressive Disease
  • Soleus Muscle
  • Short Latency
  • Asymptomatic Individual
  • Asymptomatic Carrier


Galvanic vestibular stimulation (GVS) is a low-cost and safe exam that tests the vestibulospinal pathway. HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a slowly progressive disease that precociously affects the vestibulospinal tract. This study compared electromyographic (EMG) responses triggered by GVS between asymptomatic individuals infected with HTLV-1 and those with HAM/TSP.


Bipolar galvanic stimuli of 400 ms and 2 mA intensity were applied on the mastoid processes in 120 trials. The EMG response, and its short latency (SL) and middle latency (ML) components, was recorded from both soleus muscles in 13 healthy, HTLV-1-negative adults (56 ± 5 years, mean ± SD), and 26 individuals infected with HTLV-1, 13 asymptomatic (56 ± 8 years) and 13 with HAM/TSP (60 ± 6 years).


The average value of EMG components in the group of healthy individuals was 55 ± 4ms (SL) and 112 ± 10ms (ML); in the group of asymptomatic HTLV-1 carriers, 61 ± 6ms (SL) and 112 ± 10ms (ML); and in the group with HAM/TSP, 67 ± 8ms (SL) and 130 ± 3ms (ML) (P=0.001). In the HTLV-1-asymptomatic group, the SL component was delayed in 4/13 (31%) exams and the ML component was normal in all. In the HAM/TSP group, the most common alteration was the absence of waves.


A pattern of abnormal vestibular-evoked EMG response was found in the HTLV-1-neurological disease, which ranged from delayed latency among asymptomatic carriers to absence of response in HAM/TSP. GVS may contribute to early diagnosis and monitoring of non-traumatic myelopathies.

Authors’ Affiliations

HTLV Interdisciplinary Research Group (HTLV-1), Belo Horizonte, Minas Gerais, Brazil
Tropical Medicine Post Graduation Program, Faculty of Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil
Foundation and Center for hematology and hemotherapy of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil


© Cunha et al; licensee BioMed Central Ltd. 2014

This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver ( applies to the data made available in this article, unless otherwise stated.