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Telomere length, proviral load and neurologic impairment in HTLV-1-and HTLV-2-infected humans

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Background

Telomeres shorten with aging and short or damaged telomeres have been implicated in degenerative conditions. We hypothesized that telomere length might be altered in chronic HTLV-1 and -2 infection and could be a marker of HTLV-associated disease and viral dynamics.

Methods

45 HTLV-1, 45 HTLV-2, and 45 seronegative subjects were selected from the larger HTLV Outcomes Study (HOST) cohort, and stratum-matched on age, sex and race/ethnicity. The telomere-to-single copy gene (T/S) ratio and HTLV-1 and -2 proviral load were measured using real-time PCR on the same PBMC samples. Unpaired t-tests, linear regression and logistic regression were used to test associations.

Results

Ln T/S ratio was inversely associated with age among seronegatives (p=.006) but HTLV-1 and -2 subjects did not show an inverse age association. There was no difference in mean T/S ratio between HTLV-1 (1.02), HTLV-2 (1.03) and matched seronegative (0.99) subjects. In HTLV-1 subjects, there was a borderline inverse association (p=0.07) between T/S ratio and log10 proviral load which did not persist after multivariate adjustment (p=0.17). Among HTLV-2 subjects only, Ln T/S ratio was significantly associated (p=0.026) with increased odds of vibration-sensation impairment.

Conclusions

We found no evidence for an overall difference in telomere length between HTLV cases and controls but there was a weak association between HTLV-1 proviral load and telomere length. The association between telomere length and impaired vibration sense in the HTLV-2-positive group is intriguing, and suggests avenues for future investigation of previously described neuropathy in that group.

Author information

Correspondence to Edward L Murphy.

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Keywords

  • Neuropathy
  • Inverse Association
  • Telomere Length
  • Neurologic Impairment
  • Weak Association