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A recombinant attenuated candidate vaccine that efficiently and persistently protects against bovine leukemia virus in herds

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There currently is no efficient vaccine that protects against bovine leukemia virus (BLV) infection. We now propose a novel approach based on the use of a recombinant live-attenuated BLV provirus. The rationale behind this strategy relies on the deletion of genes required to induce pathogenesis maintaining the integrity of those involved in infectivity. We have identified a BLV attenuated provirus that is infectious but replicates at reduced levels in cattle. The attenuated strain elicits a strong anti-BLV immune response and does not spread to uninfected sentinels maintained during 3 years in the same herd supporting biosafety of the vaccine. Passive antibodies are transmitted to newborn calves via maternal colostrum and persist during several months. Nevertheless, the BLV attenuated provirus does not transmit from cows to calves. Finally, vaccinated animals resist challenge by a wild-type BLV virus. In summary, we have identified a safe BLV attenuated provirus with impaired transmissibility that efficiently protects against infection in herd conditions.

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Correspondence to Sabrina M Rodríguez.

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This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Keywords

  • Immune Response
  • Leukemia
  • Infectious Disease
  • Cancer Research
  • Leukemia Virus