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Table 1 Genes differing by 2-fold or more expression between Ag and Ag + Ant treatment

From: A CD4+T cell antagonist epitope down-regulates activating signaling proteins, up-regulates inhibitory signaling proteins and abrogates HIV-specific T cell function

Gene Fold change Function Reference
FOS 5.58 Immediate early gene transcription factor, up-regulated in response to extracellular signals like chemokines and cytokines  
CCL3L1 5.07 Codes for protein (Mip-1α) that binds CCR5 and caused internalization of CCR5, preventing HIV entry [34, 35]
IL8 4.81 Inflammatory cytokine produced by T cells, cell chemoattractant  
EGR2 4.75 Early growth response protein, responsible for regulation cell activation, overexpression leads to inhibition of T cell activation [36]
NR4A2 4.62 Involved in T cell homeostasis  
NR4A3 4.33 Involved in T cell homeostasis  
DUSP2 3.83 Phosphatase that inactivate MAP kinase cascade, negatively regulate proliferation and differentiation [37, 38]
CSF2 3.49 Cell growth factor  
TNFSF9 3.26 TNF superfamily trans-membrane glycoprotein expressed on activated T cells  
MAP3K8 2.97 Activates MAP and JNK kinase pathways and induces NF-κB, promotes TNF-α and IL-2 during T cell activation [39, 40]
TNF 2.96 Pro-inflammatory cytokine  
CD69 2.94 Early inducible surface glycoprotein, functions as signal transducing receptor  
EGR1 2.85 Early growth response protein, enhances T cell function [36]
SPRY1 2.77 Inhibits TCR signaling in differentiated cells, enhances TCR signaling in naïve cells [41]
IFNG 2.71 Pro-inflammatory cytokine, antiviral and immunoregulatory functions  
TAGAP 2.63 Rho GTPase activating protein, role in T cell activation  
FOSB 2.62 Proteins that dimerize with JUN, form AP-1 transcription complex, role in proliferation and differentiation [42]
CCL3 2.48 Pro-inflammatory cytokine (MIP-1α), natural ligand for CCR5 [43]
BTG2 2.47 Negative regulator of cell cycle [44]
GADD45B 2.44 Increased levels observed following cell stress, inhibit cell growth [45]
CCL3L3 2.44 Cytokine involved in immunoregulatory and inflammatory process, can bind to CCR5, inhibits HIV entry [34, 35]
NR4A1 2.27 Can block activation through NF-κB, [46]
PDCD1 2.23 Negatively regulates TCR signals [47]
EGR4 2.17 Interacts with NF-κB, controls transcription of genes encoding inflammatory cytokines including IL-2 [48]
ZFP36 2.1 Binds to 3’-UTR of some cytokines and promotes their degradation [49]
PTGS2 2.09 Cox-2 has been shown to be Involved in Th1 differentiation  
NFKBID 2.03 Member of NF-κB inhibitor family  
FASLG 2.02 FAS-FASL binding is involved in T-cell homeostasis  
FAM53C 2.00 Unknown function  
GJB2 -2.13 Gap junction beta-2 protein  
HBB -2.20 Haemoglobin beta subunit  
SPDEY9P -2.25 Speedy/RINGO cell cycle regulator family member E9  
CCR7 -2.28 G-protein coupled family receptor involved in T cell migration  
  1. Top up-regulated genes in gene array data.
  2. Fold change was calculated and Ag + Ant was subtracted from Ag treatment. Data were then sorted from highest to lowest. The top genes that changed from Ag compared to Ag + Ant treatment are shown. Data are presented in Log base 2.