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Figure 3 | Retrovirology

Figure 3

From: A Cyclin T1 point mutation that abolishes positive transcription elongation factor (P-TEFb) binding to Hexim1 and HIV tat

Figure 3

Conservation of Hexim and Cyclin T proteins. (A) Alignment of Cyclin T amino-acid sequences from Homo sapiens (CycT1 and CycT2); Drosophila melanogaster (dCycT); Caenorhabditis elegans (cit-1.2). CycT1 residues generated by random mutagenesis that resulted in Hexim1 binding deficiency are highlighted in black. Numbers above the sequences correspond to the a.a. number in the human Hexim1 and Cyclin T1 sequences respectively. (B) Alignment of Hexim amino-acid sequences from Homo sapiens (HsHEX1 and HsHEX2); Drosophila melanogaster (DmHEX); Caenorhabditis elegans (CeHEX). Nematode residues conserved in metazoa are highlighted in yellow. Residues highlighted in black are required for Cyclin T1 binding in a two-hybrid assay.

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Retrovirology

ISSN: 1742-4690

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