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Figure 3 | Retrovirology

Figure 3

From: Antigenic and 3D structural characterization of soluble X4 and hybrid X4-R5 HIV-1 Env trimers

Figure 3

Kinetics of 447-52D antibody binding to gp140 constructs with SPR measurements. ProteOn XPR36 measurements were performed with immobilized 447-52D antibody (ligand) and rising concentrations of the different gp140 constructs (analyte). Note the remarkable slower dissociation of the NL4-3/ADA construct from the 447-52D mAb in contrast to the NL4-3 and ADA construct, which is responsible for its higher affinity to 447-52D (see also Figure 2 and table of Additional file 6 with listed KD, kon and koff rates).

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