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Table 1 Neutralizing and binding properties of bNAbs: stoichiometry, off-rate constant, and persistent fraction (PF)

From: Differential binding of neutralizing and non-neutralizing antibodies to native-like soluble HIV-1 Env trimers, uncleaved Env proteins, and monomeric subunits

NAb S m k off1 (1/s) Log PF
VRC01 (n = 6)a 1.6 4.7 . 10−6 −3.7 ± 0.80
PGV04 (n = 4) 1.5 <1.0 . 10−5 −2.5 ± 0.17
PGT121 (n = 10) 1.7 8.5 . 10−6 −2.8 ± 0.089
PGT122 (n = 8) 1.6 3.0 . 10−6 −3.2 ± 0.39
PGT123 (n = 8) 2.0 9.5 . 10−6 −3.1 ± 0.14
2G12 (n = 6) 2.9 1.5 . 10−4 −1.2 ± 0.082
PG9 (n = 6) 0.97 7.1 . 10−4 −2.1 ± 0.12
PG16 (n = 8) 0.96 2.7 . 10−3 −1.6 ± 0.071
PGT145 (n = 6) 0.78 6.9 . 10−4 −1.3 ± 0.12
PGT151 (n = 6) 1.8 3.5 . 10−4 −3.0 ± 0.086
  1. aThe values in the Table are derived from global non-linear regression fits of data from n replicate neutralization titrations ± s.e.m. for the logarithmic PF values. The n values for SPR analyses are given in Additional file 3: Tables S4 and S5, where the S m and k off1 are included ± s.e.m.