| TSS <3 kb (immediate) | 3-10 kb (intermediate) | Beyond 10 kb (distal) |
---|
Complete (n = 6117) | 1602 (26%) | 1186 (29%) | 3329 (54%) |
Median distance (bp) | 868 | 5872 | 33169 |
H3K4Me1/H3K27Ac | 1494 (93%) | 1062 (90%) | 2757 (83%) |
H3K4Me3 | 902 (56%) | 164 (14%) | 479 (14%) |
Reduced (n = 2127) | 604 (28%) | 348 (16%) | 1175 (55%) |
Median distance (bp) | 800 | 5924 | 37532 |
H3K4Me1/H3K27Ac | 551 (91%) | 272 (78%) | 803 (68%) |
H3K4Me3 | 438 (73%) | 59 (17%) | 137 (12%) |
- Summary of the colocalization-analyses between retroviral integrations in tumors and ChIP-seq enhancer (H3K4Me1 and H3K27Ac) markers. The far majority of integrations are located at intermediate and distal positions relative to TSSs. The median distance to TSSs of integrations in each cluster is shown, as well as the total number of integrations that colocalized with ChIP-seq markers from thymus and spleen, combined. Statistics concerning the H3K4Me3 marker shows integrations that also colocalized with enhancer markers.