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Table 3 Wild-type MLVs show a strong propensity for insertion into enhancers irrespective of their distance to UCSC TSSs

From: Novel principles of gamma-retroviral insertional transcription activation in murine leukemia virus-induced end-stage tumors

  TSS <3 kb (immediate) 3-10 kb (intermediate) Beyond 10 kb (distal)
Complete (n = 6117) 1602 (26%) 1186 (29%) 3329 (54%)
Median distance (bp) 868 5872 33169
H3K4Me1/H3K27Ac 1494 (93%) 1062 (90%) 2757 (83%)
H3K4Me3 902 (56%) 164 (14%) 479 (14%)
Reduced (n = 2127) 604 (28%) 348 (16%) 1175 (55%)
Median distance (bp) 800 5924 37532
H3K4Me1/H3K27Ac 551 (91%) 272 (78%) 803 (68%)
H3K4Me3 438 (73%) 59 (17%) 137 (12%)
  1. Summary of the colocalization-analyses between retroviral integrations in tumors and ChIP-seq enhancer (H3K4Me1 and H3K27Ac) markers. The far majority of integrations are located at intermediate and distal positions relative to TSSs. The median distance to TSSs of integrations in each cluster is shown, as well as the total number of integrations that colocalized with ChIP-seq markers from thymus and spleen, combined. Statistics concerning the H3K4Me3 marker shows integrations that also colocalized with enhancer markers.