Figure 2From: Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibodysdAb19 targets a C-terminal surface epitope on Nef. (A) Binding of sdAb19 to NefSF2. The three complementarity determining regions are colored yellow (CDR1), red (CDR2), and blue (CDR3), respectively. (B) Residues of CDR2 are significantly involved in the interaction with Nef. Hydrogen bonds and salt bridges are displayed as dashed lines. (C) Interaction map of Nef and sdAb19 within a distance shell of 3.7 Å. Hydrophobic and polar interactions between main chain (dots) and side chain (bars) atoms are indicated by dashed lines colored grey and blue, respectively. For hydrogen bonds and salt bridges the inter-atomic distances are tabulated.Back to article page