Figure 4

Highlighter plot and hamming distance analyses of T/F env in R5 SHIV _SF162P3N ivg-infected macaques. Data for env V3-V5 sequences from representative transiently viremic (TV; AH84), chronically-infected (CP; FR25, GH62) or rapidly-progressing (RP; EI77, DG17, EL48) macaques is shown. Positions of nucleotide base transitions and transversions in the highlighter plots are indicated by short, colored coded bars. Colors are as follows: A: green, T: red, G: yellow. C: blue and gaps: grey. Tics that are bracketed represent G-to-A changes while those in circles represent G-to-A changes in a sequence consistent with an APOBEC signature. The number of identifiable T/F viruses is listed on the left.