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Figure 1 | Retrovirology

Figure 1

From: Linkages between HIV-1 specificity for CCR5 or CXCR4 and in vitrousage of alternative coreceptors during progressive HIV-1 subtype C infection

Figure 1

Alternative coreceptor usage by R5 C-HIV Envs. Luciferase reporter viruses pseudotyped with each of the C-HIV R5 Envs (n = 294) were used to infect NP2-CD4 cells expressing CCR5, FPRL1, CCR3 or CCR8, and the levels of HIV-1 entry were determined as described in the Methods. The background level of luciferase activity, as determined by infections with luciferase reporter virus pseudotyped with the non-functional ΔKS Env [44], is shown by the horizontal dashed line. The data shown are the means and standard deviations of entry levels of all the R5 C-HIV Envs in the different cell types, and are representative of 3 independent experiments, each performed in triplicate. The individual dots represent mean entry levels of triplicates from a representative experiment. Statistical comparisons were made using a Mann–Whitney U test. P values < 0.05 were considered statistically significant.

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Retrovirology

ISSN: 1742-4690

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