Figure 8
From: HIV latency and integration site placement in five cell-based models
Shared expression status between near neighbors. The ratio of the number of pairs of proviruses with matching expression status to the number of matches expected by random pairings given the frequency of silent/inducible proviruses. All possible pairs of proviruses integrated within a given distance of each other on the same chromosome (red line) were separated into two sets; one with both proviruses from within the same cell culture model and one with proviruses paired between two different cell culture models (black lines). The shaded region shows the 95% Clopper-Pearson binomial confidence interval for within and between sample pairings. The dashed horizontal line shows the ratio of 1 expected if there is no association between the expression status of neighboring proviruses.