Severe CD4+ T cell loss in RMs infected with SHIV
molecular clones. (A) Plasma viral load and peripheral CD4+ T cell count in RMs that developed clinical symptoms of AIDS. Horizontal line denotes CD4+ T cell count of 200 cells/ul blood. (B) Percentages of CD4+ T cells in the lamina propria lymphocyte (LPL) from the jejunum, iliac, colonic (col) and mesenteric (Mes) lymph nodes during acute viremia (2 wpi) and at time of necropsy. Baseline values generated from three uninfected macaques are shown for reference.