Figure 1

Localization of missense variants in human tetherin. (A) Codons containing non-synonymous variants in the tetherin gene are boxed in red. Non-synonymous exchanges are indicated above the nucleotide sequence and the predicted amino acid changes are shown below the protein frame. The Kozak sequence of the tetherin gene is highlighted in grey and both alternative start codons are indicated by arrows. Cysteine residues involved in dimerization and the two N-linked glycosylation sites are indicated in yellow and green respectively. ω marks the omega site of GPI anchor addition. (B) Schematic presentation of the position of the variants in regard to the structural elements of tetherin. Tetherin is depicted as a dimer and the two glycosylation sites are indicated.