Figure 7

Influence of ART on the divergence of the viral population. Each group contains 10 individuals. Control, non-treated individuals; ART12, short course antiretroviral therapy (12 weeks); ART48, long course antiretroviral therapy (48 weeks). The divergence is shown as mean intra-patient root to tip distance, defined as genetic distance (in number of nucleotide substitutions per site) from each sequence to the root. Distances were calculated under the uncorrected (p) model of nucleotide substitution (number of substitutions accumulated along the path from the tip to the root, divided by the length of the alignment). Root to tip distances were analysed over a time of ~ 60 weeks after primary infection. The significance of differences in the mean between groups was tested by Wilcoxon rank sum tests. There is no significant difference between the control group and ART12 (p = 0.780).