Figure 8
From: Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
Site-directed mutagenesis of the first, second, third and fifth conserved Bet motif. FFV Bet contains 387 amino acids and consists of Bel1 and Bel2 sequences as indicated. Conserved motifs are represented as gray boxes and conserved motif 1, 2, 3 and 5 are underlined. Motifs 4 and 6 were not analyzed. Alanine residues that substitute the original residues are marked in bold. Numbers in brackets indicate the positions of the first amino acid in a given sequence. Mutations that did not impair Bet functions are marked with (+) and bolded names. Grey (+) signs indicates incomplete restoration of FFV titers by certain mutants.