Figure 1
From: Identification of the feline foamy virus Bet domain essential for APOBEC3 counteraction
Bet proteins of different FVs contain six conserved motifs. (A) Genome organisation of FVs. The regulatory and accessory bel1 and bel2 genes are localized between env and the 3′LTR. The Bet protein is a product of a spliced transcript and consists of Bel1 and Bel2 parts. (B) Bioinformatics using the MEME program identified six conserved motifs localized in Bel2. Motifs are represented as gray boxes in the figure and the sequences are given below as well as the consensus sequence. Numbers in brackets indicate the position of the first amino acid of the motifs. In EFV Bet motifs 2 and 3 are found in reversed order. Motifs and residues that were not experimentally studied due to low degrees of conservation, such as motifs 4 and 6 and residues flanking motif 3, are represented in light shading and font, respectively. FFV, feline FV; BFV, bovine FV; EFV, equine FV; PFV, prototype/primate/human FV; SFV, simian FV; SloEFV, sloth endogenous FV.