Figure 1

Combined H-iART/auranofin treatment induces peculiar CD4⁺ T-cell subpopulation rearrangements in SIVmac251-infected macaques. Panels A-E. Dynamics over time of percentages (mean and SEM) and absolute numbers (means and SEM) of T_N (red), T_CM (green) and T_EM (black) CD4⁺ T-cells in macaques treated with: auranofin and H-iART (Panels A,B); auranofin and iART, i.e. H-iART without maraviroc (panels C-D); H-iART only (panel E). Total cell counts of macaques treated with H-iART only have been presented in Ref. [12]. Panel F. Dynamics over time of the difference between the average relative proportions of T_N and T_CM cells (Δ T_N -T_CM). Asterisks mark the significant differences with baseline (i.e., time 0) values (* P < 0.05; ** P < 0.01; *** P < 0.001), which were calculated by repeated measures ANOVA followed by Student-Newman-Keuls post-test (panels A-E). Note that percentage values (panels A, C and E) and absolute values (panels B and D) were subjected to LOGIT or Log transformation, respectively, before being subjected to the statistical test. The P value in panel F refers to the significant difference between curves (extra sum-of-squares F test) and was calculated after restoring normality with a LOGIT transformation of the data.