Molecular models of dATP and EFdA-TP in the active sites of WT and K65R HIV RT. dATP (yellow sticks, A and C) and EFdA-TP (cyan sticks, B and D) are shown at the active sites of WT HIV RT, (A and B) or K65R HIV RT (C and D). The fingers and palm subdomains are shown in blue and red cartoon, respectively. The primer and template strands are shown in dark gray and light gray sticks, respectively. Figures were made using PyMOL (The PyMOL Molecular Graphics System, Version 1.3 Schrödinger, LLC).