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Figure 4 | Retrovirology

Figure 4

From: Increased expression of OX40 is associated with progressive disease in patients with HTLV-1-associated myelopathy/tropical spastic paraparesis

Figure 4

Expression of OX40 in inflammatory mononuclear cells in spinal cord lesions of HAM/TSP patient with short disease duration and progressive symptoms. We studied autopsy specimens from 9 HAM/TSP patients by immunohistochemical staining. A. No OX40 positive cells are detected in the spinal cord lesion without active inflammation of a HAM/TSP patient with a long duration of illness. Magnification: ×40. B. Many infiltrating mononuclear cells are positively stained by anti-OX40 mAb in the spinal cord lesion with active inflammation of HAM/TSP patient with 2.5 years of illness. Magnification: ×40. C. There was reduced or no OX40L protein expression in spinal cord tissues of HAM/TSP patients. OX40L showed only low background staining and there was no OX40L positive staining on inflammatory mononuclear cells in the spinal cord lesions. Magnification: ×20. D. Positive control staining for OX40L positive CEM-OX40L cells. Magnification: ×20. Bar: 50 μm.

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Retrovirology

ISSN: 1742-4690

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