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Figure 2 | Retrovirology

Figure 2

From: The NTD-CTD intersubunit interface plays a critical role in assembly and stabilization of the HIV-1 capsid

Figure 2

Impaired replication of NTD-CTD mutants in CEM cells. (A) Structural view of the NTD-CTD interface showing two different subunits, NTD1 (blue) and CTD2 (red) and the side chains of residues target for mutagenesis. (B and C) CEM cells were inoculated with 5 ng of virus or an equivalent quantity based on RT units. Supernatants were sampled from the culture media after every 3 days as indicated and viral accumulation analyzed by p24 ELISA or by in vitro RT assay. The results shown are the mean values of duplicate determinations.

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Retrovirology

ISSN: 1742-4690

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