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Table 2 IN mutations of NL-ADA or NL-IN-D64A-ADA viruses in Figure 5 B and 5 C

From: DNA damage enhances integration of HIV-1 into macrophages by overcoming integrase inhibition

Virus

Clone #

RNA

Amino acid

WT/RAL

#1

-

-

 

#5

-

-

 

#6

-

-

 

#7

-

-

 

#8

-

-

 

#9

-

-

 

#10

-

-

 

#2

A144G

E48E (Silent)

 

#3

A87G

P29P (Silent)

 

#4

A731G

R244K

D64A/DMSO

#1

A191C

D64A

 

#2

A191C

D64A

 

#3

A191C

D64A

 

#4

A191C

D64A

 

#7

A191C

D64A

 

#9

A191C

D64A

 

#5

A191C, A772G

D64A, K258E

 

#6

A191C, U842A

D64A, V281E

 

#8

A38G, A191C, G462A

E13G, D64A, M154I

 

#10

A191C, A279, A809G

D64A, T93T (Silent), D270G

D64A/RAL

#1

A191C

D64A

 

#4

A191C

D64A

 

#8

A191C

D64A

 

#10

A191C

D64A

 

#2

A191C, G806C

D64A, R269T

 

#3

A191C, A718G

D64A, K240E

 

#5

A191C, G829U

D64A, G277C

 

#6

A191C, U598C

D54A, I200T

 

#9

A191C, G462A

D64A, M154I

 

#7

G7A, G39A, G103A, A191C

D3N, E13E (Silent), E35K, D64A

  1. Nucleotide sequence of progeny viral RNA was analyzed. In two of 20 clones examined, we identified M1541, which was reported as a mutation related to RAL-resistant phenotype [30].