Figure 8From: N-terminal Slit2 inhibits HIV-1 replication by regulating the actin cytoskeletonProposed mechanism of Slit2N-mediated inhibition of HIV-1 entry. Slit2N inhibits HIV-1 envelope-induced Rac1/LIMK1/cofilin pathway, thus attenuating actin polymerization, ultimately blocking virus entry. Furthermore, Slit2N also inhibits HIV-1 envelope-induced Robo1/actin association, possibly modulating cytoskeletal rearrangements that facilitate HIV-1 entry.Back to article page